Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS

TitleRobust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS
Publication TypePublication
Year2022
AuthorsPan Y, Wang D, Chaudhary MFA, Shao W, Gerard SE, Durumeric OC, Bhatt SP, R Barr G, Hoffman EA, Reinhardt JM, Christensen GE
JournalJ Imaging
Volume8
Issue11
Date Published2022 Nov 16
ISSN2313-433X
Abstract

Chronic obstructive pulmonary disease (COPD) is an umbrella term used to define a collection of inflammatory lung diseases that cause airflow obstruction and severe damage to the lung parenchyma. This study investigated the robustness of image-registration-based local biomechanical properties of the lung in individuals with COPD as a function of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Image registration was used to estimate the pointwise correspondences between the inspiration (total lung capacity) and expiration (residual volume) computed tomography (CT) images of the lung for each subject. In total, three biomechanical measures were computed from the correspondence map: the Jacobian determinant; the anisotropic deformation index (ADI); and the slab-rod index (SRI). CT scans from 245 subjects with varying GOLD stages were analyzed from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). Results show monotonic increasing or decreasing trends in the three biomechanical measures as a function of GOLD stage for the entire lung and on a lobe-by-lobe basis. Furthermore, these trends held across all five image registration algorithms. The consistency of the five image registration algorithms on a per individual basis is shown using Bland-Altman plots.

DOI10.3390/jimaging8110309
Alternate JournalJ Imaging
PubMed ID36422058
PubMed Central IDPMC9693030
Grant ListHL142625 / NH / NIH HHS / United States
MS#: 
MS212
Manuscript Full Title: 
Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS
Manuscript Lead/Corresponding Author Affiliation: 
Reading Center: Radiology (University of Iowa)
ECI: 
Manuscript Status: 
Published and Public