Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.

TitleStructural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.
Publication TypePublication
Year2019
AuthorsBin Cho H, Chae KJu, Jin GYong, Choi J, Lin CLong, Hoffman EA, Wenzel SE, Castro M, Fain SB, Jarjour NN, Schiebler ML, R Barr G, Hansel N, Cooper CB, Kleerup EC, Han MK, Woodruff PG, Kanner RE, Bleecker ER, Peters SP, Moore WC, Lee CHyun, Choi S
Corporate AuthorsNational Heart, Lung and Blood Institute's SubPopulations and InteRmediate Outcome Measures In COPD Study(SPIROMICS) and Severe Asthma Research Program(SARP)
JournalKorean J Radiol
Volume20
Issue7
Pagination1236-1245
Date Published2019 Jul
ISSN2005-8330
KeywordsAdult, Aged, Asians, asthma, Female, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Non-Smokers, Prevalence, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Republic of Korea, Respiratory Function Tests, Retrospective Studies, Tomography, X-Ray Computed, United States, Whites
Abstract

OBJECTIVE: Considering the different prevalence rates of diseases such as asthma and chronic obstructive pulmonary disease in Asians relative to other races, Koreans may have unique airway structure and lung function. This study aimed to investigate unique features of airway structure and lung function based on quantitative computed tomography (QCT)-imaging metrics in the Korean Asian population (Koreans) as compared with the White American population (Whites).MATERIALS AND METHODS: QCT data of healthy non-smokers (223 Koreans vs. 70 Whites) were collected, including QCT structural variables of wall thickness (WT) and hydraulic diameter (D) and functional variables of air volume, total air volume change in the lung (ΔV), percent emphysema-like lung (Emph%), and percent functional small airway disease-like lung (fSAD%). Mann-Whitney U tests were performed to compare the two groups.RESULTS: As compared with Whites, Koreans had smaller volume at inspiration, ΔV between inspiration and expiration ( < 0.001), and Emph% at inspiration ( < 0.001). Especially, Korean females had a decrease of ΔV in the lower lobes ( < 0.001), associated with fSAD% at the lower lobes ( < 0.05). In addition, Koreans had smaller D and WT of the trachea (both, < 0.05), correlated with the forced expiratory volume in 1 second (R = 0.49, 0.39; all < 0.001) and forced vital capacity (R = 0.55, 0.45; all < 0.001).CONCLUSION: Koreans had unique features of airway structure and lung function as compared with Whites, and the difference was clearer in female individuals. Discriminating structural and functional features between Koreans and Whites enables exploration of inter-racial differences of pulmonary disease in terms of severity, distribution, and phenotype.

DOI10.3348/kjr.2019.0083
Alternate JournalKorean J Radiol
PubMed ID31270987
PubMed Central IDPMC6609438
Grant ListS10 OD018526 / OD / NIH HHS / United States
K24 HL137013 / HL / NHLBI NIH HHS / United States
U01 HL114494 / HL / NHLBI NIH HHS / United States
U10 HL109164 / HL / NHLBI NIH HHS / United States
U10 HL109086 / HL / NHLBI NIH HHS / United States
S10 RR022421 / RR / NCRR NIH HHS / United States
HHSN268200900013C / HL / NHLBI NIH HHS / United States
R01 HL112986 / HL / NHLBI NIH HHS / United States
P30 ES005605 / ES / NIEHS NIH HHS / United States
U01 HL137880 / HL / NHLBI NIH HHS / United States
U10 HL109152 / HL / NHLBI NIH HHS / United States
MS#: 
MS182
Manuscript Full Title: 
Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.
Manuscript Lead/Corresponding Author Affiliation: 
Reading Center: Radiology (University of Iowa)
ECI: 
Manuscript Status: 
Published and Public