Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).

TitleDesign of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).
Publication TypePublication
Year2014
AuthorsCouper D, LaVange LM, Han ML, R Barr G, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S
Corporate AuthorsSPIROMICS Research Group
JournalThorax
Volume69
Issue5
Pagination491-4
Date Published2014 May
ISSN1468-3296
KeywordsAdult, Aged, Aged, 80 and over, biomarkers, Disease Management, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Spirometry, Surveys and Questionnaires, Tomography, X-Ray Computed
Abstract

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.
DOI10.1136/thoraxjnl-2013-203897
Alternate JournalThorax
PubMed ID24029743
PubMed Central IDPMC3954445
Grant ListHHSN268200900019C / HL / NHLBI NIH HHS / United States
HHSN268200900009C / WH / WHI NIH HHS / United States
R01HL110906 / HL / NHLBI NIH HHS / United States
HHSN268200900015C / HL / NHLBI NIH HHS / United States
HHSN268200900018C / HL / NHLBI NIH HHS / United States
HHSN268200900014C / HL / NHLBI NIH HHS / United States
R01 HL112986 / HL / NHLBI NIH HHS / United States
P30 ES005605 / ES / NIEHS NIH HHS / United States
HHSN268200900016C / HL / NHLBI NIH HHS / United States
R01 HL110906 / HL / NHLBI NIH HHS / United States
HHSN268200900017C / HL / NHLBI NIH HHS / United States
HHSN268200900020C / HL / NHLBI NIH HHS / United States
HHSN268200900013C / HL / NHLBI NIH HHS / United States
HHSN2682009000019C / / PHS HHS / United States
MS#: 
MS002
Manuscript Full Title: 
Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).
Manuscript Lead/Corresponding Author Affiliation: 
Genomics and Informatics Center (University of North Carolina at Chapel Hill)
ECI: 
Manuscript Status: 
Published and Public